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Fig. 1. | Molecular Medicine

Fig. 1.

From: Influenza Virus Infection is not Affected by Serum Amyloid P Component

Fig. 1.

Influenza infection in C57BL/6 wild type and SAP knockout mice. Upper panel, body weight (left) and survival (right) following intra-nasal infection on day 0 with the A/PR/8/34 viral strain, in 27 female wild type mice ( and solid line) aged 15–16 weeks, mean (SD) initial body weight 24.0 (1.6) g, and 31 female SAP knockout mice (□ and broken line) aged 13–20 weeks, mean (SD) initial body weight 27.3 (1.8) g. Lower panel, body weight (left) and survival (right) following intranasal infection on day 0 with the A/WS/33 ATCC VR1520 viral strain, in 34 female wild type mice ( and solid line) aged 10–13 weeks, mean (SD) initial body weight 20.5 (1.9) g, and 27 female SAP knockout mice (□ and broken line) aged 8–25 weeks, mean (SD) initial body weight 25.0 (2.7) g. Each point (left panels) represents the mean (SD) of all surviving animals in each group at each time point; significant differences between groups by t-test are shown by P values. In the milder infection (upper panel) the wild type mice showed greater percentage weight loss, but in the more severe infection (lower panel) the wild type animals showed less weight loss. In both experiments the SAP knockout mice had a wider age range, owing to their breeding pattern and the need to have substantial sized groups, and also had a greater mean initial weight. However there was no difference in survival between SAP knockout and wild type mice in either case, indicating that initial weight had no systematic effect on morbidity or outcome.

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