Aortic TF and TFPI expression. (A) TF (open bar) and TFPI (grey bar) mRNA expression in the arterial wall. A significant increase in TF mRNA was observed; TFPI mRNA expression was not modified by l-NAME treatment. Evolution of TF activity in homogenates of media (B) and adventitia (C). A significant increase in TF activity was observed in the aortic layers in the l-NAME group. TF activity of the adventitia was strongly correlated with systolic BP (D; r = 0.73, p < 0.0001, all animals). Values are means ± SEM. **p < 0.005 versus the control group. $p < 0.05, $$p < 0.005 versus l-NAME.