Renal TF and TFPI expression. (A) mRNA expression. TF mRNA expression (open bar) was not increased in the glomeruli of l-NAME rats. Nevertheless, TFPI mRNA expression (gray bar) was significantly decreased in this group. Evolution of TF activity in intact (i) or disrupted (d) glomeruli (B) and in disrupted arterioles (C). A significant increase in TF activity was observed in arterioles of the l-NAME rats. By contrast, no variation of TF activity was observed in glomeruli. TF activity of arterioles was strongly correlated with systolic BP (D; r = 0.76, p < 0.0001, all animals). Values are means ± SEM. *p < 0.05 versus controls. $p < 0.05 versus l-NAME.