Fig. 3

In vivo synergistic effects between Anti-MDM2 oligonucleotide, Oligo AS, and chemotherapeutic agents HCPT and 5-FU in mice bearing human colon cancer LS174T xenografts. Doses for drugs alone or in combinations are Oligo AS and ASM, 20 mg/kg/day; HCPT, 3 mg/kg/day for the first week and 3 mg/kg every other day for remaining treatment period; and 5-FU, 10 mg/kg/day. The therapeutic effects for each treatment are listed in Table 1. The host toxicity (survival rate) is listed in Table 2. Synergistic or additive effects on tumor growth were noted in combination therapy.