Molecular Medicine

Table 2 Survival rates of animals bearing LS174T xenografts and treated with anti-MDM2 oligonucleotide administered alone or in combination with cytotoxic agents

From: Anti-Tumor Efficacy of a Novel Antisense Anti-MDM2 Mixed-Backbone Oligonucleotide in Human Colon Cancer Models: p53-Dependent and p53-Independent Mechanisms

Day AS		No Oligo (%)	+ ASM (%)	+ Anti-MDM2 (%)
3	Oligo alone	100	100	100
	HCPT	100	100	100
	5-FU	100	100	100
6	Oligo alone	100	100	100
	HCPT	100	100	100
	5-FU	100	100	100
9	Oligo alone	100	100	100
	HCPT	67	83	83
	5-FU	100	100	83
12	Oligo alone	100	100	100
	HCPT	50	83	83
	5-FU	100	100	83
15	Oligo alone	100	100	100
	HCPT	50	67	83
	5-FU	100	100	83
18	Oligo alone	100	100	100
	HCPT	50	67	67
	5-FU	100	100	83

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ISSN: 1528-3658

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