Factors | Status in the Spectrum of Aggressiveness (from TCs to SCLC) | References |
---|---|---|
Aneuploidy | Increasing | |
Bak | Highly expressed in carcinoids | |
Bax | Decreasing | |
Bcl-2 | Increasing (decrease in metastatic SCLCs) | |
BCL-X | Expressed in TCs | |
c-ets-1 | Highly expressed in high-grade NE tumors | |
CD44S | Decreasing | |
CD44v6 | Its loss is associated with aggressivity | |
CD99 | Expressed only in TCs | |
Ki-67 labeling | Increasing | |
MCL-1 | Highly expressed in carcinoids | |
PAI-1 | Increasing | |
PAI-2 | Decreasing | |
p53 | Increasing | |
Rb | Decreasing | |
Topo II α | Increasing (although there are no reports for LCLCs) | |
u-PA | Increasing |