Fig. 7From: PI3K Blockade by Ad-PTEN Inhibits Invasion and Induces Apoptosis in Radial Growth Phase and Metastatic Melanoma CellsAd-PTEN inhibits angiogenesis in vitro. HUVEC cells were transduced with Ad-Luc or Ad-PTEN (3000 vp/cell) or treated with Suramin or media for 24 hr. The cells were then plated onto Matrigel and incubated at 37°C. Control HUVEC exhibited mature tube formation by 12–16 hr after plating whereas Suramin and Ad-PTEN treatment blocked tube structure formation.Back to article page