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Fig. 7 | Molecular Medicine

Fig. 7

From: PI3K Blockade by Ad-PTEN Inhibits Invasion and Induces Apoptosis in Radial Growth Phase and Metastatic Melanoma Cells

Fig. 7

Ad-PTEN inhibits angiogenesis in vitro. HUVEC cells were transduced with Ad-Luc or Ad-PTEN (3000 vp/cell) or treated with Suramin or media for 24 hr. The cells were then plated onto Matrigel and incubated at 37°C. Control HUVEC exhibited mature tube formation by 12–16 hr after plating whereas Suramin and Ad-PTEN treatment blocked tube structure formation.

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