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Table 2 Histologic changes in vital organs after the treatment with IL13-PE38QQR*

From: Improved Anti-tumor Activity and Safety of Interleukin-13 Receptor Targeted Cytotoxin by Systemic Continuous Administration in Head and Neck Cancer Xenograft Model

 

Intravenous Administration

Continuous Infusion

 

150 µ g/kg

200 µ g/kg

200 µ g/kg

300 µ g/kg

Liver

Mild multi-focal necrosis, hydrophilic degeneration of pericentral vein cells

Atrophic change, Severe multi-focal necrosis, collapse of structure

NC

Mild cell degeneration

Lung

NC+

Alveolar wall thickness

NC

NC

Kidney

Cell hypertrophy, mild focal necrosis, basement thickness

Multi-focal necrosis

NC

Cell hypertrophy

Spleen

Fibrosis

Pulp degeneration

NC

NC

  1. * Data represent common findings from two animals in each group.
  2. † NC, no remarkable change.
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Molecular Medicine

ISSN: 1528-3658