Fig. 1From: Molecular Evidence-Based Use of Bone Resorption-Targeted Therapy in Prostate Cancer Patients at High Risk for Bone InvolvementLocal mediators of tumor cell survival and tumor cell-induced osteoblastic reaction at the sites of skeletal metastasis in prostate cancer. Note the pivotal role of IL-6, PTHrP, and uPA/IGFBPs/IGFs/TGF-β1 bioregulation system into these processes.Back to article page