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Fig. 4 | Molecular Medicine

Fig. 4

From: Molecular Evidence-Based Use of Bone Resorption-Targeted Therapy in Prostate Cancer Patients at High Risk for Bone Involvement

Fig. 4

Schematic illustration of the histologic types of bony lesions, a result of specific cell-cell interactions established at the sites of metastasis. Tumor cell interactions with osteoblasts and osteoclasts can be coupled in a manner that can favor either bone formation or bone resorption, resulting in the development of osteoblastic, osteolytic, and/or mixed histologic types of bony lesions.

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