Fig. 4From: Molecular Evidence-Based Use of Bone Resorption-Targeted Therapy in Prostate Cancer Patients at High Risk for Bone InvolvementSchematic illustration of the histologic types of bony lesions, a result of specific cell-cell interactions established at the sites of metastasis. Tumor cell interactions with osteoblasts and osteoclasts can be coupled in a manner that can favor either bone formation or bone resorption, resulting in the development of osteoblastic, osteolytic, and/or mixed histologic types of bony lesions.Back to article page