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Table 1 Dose-response effect of gp 120 on tubular cell caspase-3 activity.

From: HIV-1 gp120-Induced Tubular Epithelial Cell Apoptosis Is Mediated Through p38-MAPK Phosphorylation

 

gp120 (ng/ml)

Control

1.0

10.0

100.0

2.3 ± 0.3

2.0 ± 0.1

5.2 ± 0.1*

10.6 ± 0.3**

  1. Equal numbers HK-2 cells were incubated in media containing either buffer (control) or gp120 (1, 10, and 100 ng/ml) for 16 hr. At the end of the incubation period, cells were harvested and prepared for the measurement of caspase-3 activity with the use of caspase-3 assay kit. Results (means ± SEM µM release of caspase-3) are from four sets of experiments.
  2. * p < 0.001 compared with control, gp120, 1 ng/ml and gp120, 100.0 ng/ml.
  3. ** p < 0.001 compared with control and gp120, 1.0 and 10.0 ng/ml.