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Fig. 4 | Molecular Medicine

Fig. 4

From: Overexpression of the Shb SH2 Domain-Protein in Insulin-Producing Cells Leads to Altered Signaling Through the IRS-1 and IRS-2 Proteins

Fig. 4

Tyrosine phosphorylation of IRS-1 (A) and IRS-2 (B) in response to serum, insulin, and IGF-1 in RIN-Neo and RIN-Shb cells. The results in Figure 3B were subjected to densitometric analysis and means ± SEM for 4–6 observations are given. The data were tested for statistical significance using one-way ANOVA on ranks (p < 0.05). Individual comparisons were performed using a paired Student’s t-test comparing with corresponding untreated control.

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Molecular Medicine

ISSN: 1528-3658