Fig. 1

Multiple-sequence alignment for 12 members of the hypothetical mycobacterial drug efflux proteins. Highly conserved motifs are displayed below the alignment; the consensus sequences of the motifs are displayed as follows: x, any amino acids; capital letters, the frequency of occurrence of the amino acids is greater that 70%; lower case letters, the frequency of occurrence of the amino acids is greater than 40%. Motifs A, B, and C correspond to the motifs described by Paulsen et al. (16). The alignment shows only the region containing the above-cited motifs. Identical amino acids are highlighted in black boxes; conserved amino acid substitutions are shown in shaded boxes.