Fig. 2

Multiple-sequence alignments for members of the mycobacterial 14- and 15-TMS (A), and 12-TMS drug efflux transporters (B), respectively. Details on these alignments can be found in the legend for Figure 1. Motifs D1, H, E, F, and G correspond to the motifs described by Paulsen et al. (16). Motif C, described as characteristic of drug export proteins, is indicated. The alignment shows only the region containing the above-cited motifs. Identical amino acids are highlighted in black boxes; conserved amino acid substitutions are shown in shaded boxes.