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Table 1 List of M. tuberculosis ORFs described as hypothetical drug efflux proteins belonging to MFS.

From: The Multidrug Transporters Belonging to Major Facilitator Superfamily (MFS) in Mycobacterium tuberculosis

Sequence

Length

Hypothetical Function*

TMS (N)

Relative Position of

Motif A

Motif B

Motif C

Rv0037c

441

Probable membrane protein

11

89–101

124–136

169–180

Rv0191

413

Probable chloramphenicol resistance protein

12

77–89

111–123

157–168

Rv0783c

540

Multidrug resistance protein

14

99–111

134–146

179–190

Rv0849

419

Possible quinolone efflux pump

12

69–81

104–116

148–159

Rv1250

579

Probable drug efflux protein

14

75–87

110–122

152–163

Rv1258c

419

Probable multidrug resistance pump

12

63–75

102–114

153–164

Rv1410c

518

Probable drug efflux protein

14

66–78

104–116

149–160

Rv1634

471

Probable drug efflux protein

14

75–87

110–122

155–166

Rv1877

687

Probable drug efflux protein

14

83–95

108–120

163–174

Rv2333c

537

Probable tetracenomycin C resistance protein

14

63–75

98–110

145–156

Rv2456c

418

Probable transmembrane transport protein

10

68–80

104–116

149–160

Rv2459

508

Probable drug efflux protein

14

63–75

98–110

145–156

Rv2846c

530

EfpA putative efflux protein

14

109–121

144–156

190–201

(EfpA)

      

Rv2994

445

Probable fluoroquinolone efflux protein

9

69–81

104–116

149–160

Rv3239c

1048

Probable drug efflux protein

15

81–93

116–128

161–172

Rv3728

1065

Possible sugar transporter

15

97–109

132–144

177–188

  1. *As reported by Cole et al. (18).