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Table 1 Mean percentage (±SEM) of lymphocyte subpopulations in spleen and thymic tissue from male rats exposed to no (0 mg/kg feed; n = 6), low (5 mg/kg feed; n = 12), or high (300 mg/kg feed; n = 12) genistein diets

From: Early Exposure to Genistein Exerts Long-Lasting Effects on the Endocrine and Immune Systems in Rats

 

Genistein (mg/kg of diet)

 

0

5

300

Spleen

   

CD4+ T cells

22.54 ± 0.73

24.23 ± 0.79

25.37 ± 0.62

CD8+ T cells

19.38 ± 1.96

22.87 ± 0.78

23.44 ± 0.80*

Total T cells‡

41.92 ± 2.21

47.10 ± 1.13*

48.81 ± 1.01*

CD45R B cells

50.22 ± 1.05

50.43 ± 1.51

47.16 ± 1.45

Thymus

   

CD−CD8− T cells

10.52 ± 3.58

4.281 ± 0.910*

4.083 ± 0.82*

CD + CD8− T cells

7.478 ± 1.830

5.287 ± 0.380

5.383 ± 0.230

CD−CD8+ T cells

6.363 ± 1.730

5.038 ± 0.430

5.642 ± 0.420

CD + CD8+ T cells

75.63 ± 7.02

85.13 ± 0.81*

84.82 ± 0.69*

  1. Data represent the percentage of lymphocytes expressing the various cell surface markers. For each dependent measure, an asterisks (*) indicates that males exposed to genistein are significantly different from genistein-free males based on a one-way ANOVA, p < 0.05.
  2. ‡ Total T cells in the spleen = the percentage of CD4+ T cells+ the percentage of CD8+ T cells.
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Molecular Medicine

ISSN: 1528-3658