Table 3 Changes in LVEF, RVEF, hemodynamics, coronary sinus norepinephrine, and peak Vo ₂ in three LV function change groups, subjects with complete mRNA measurements ( n = 15/group)

LVEF (EF units)

−2.2 ± 1.1^§

12.2 ± 0.9*^,†

25.5 ± 1.8*^,#,†

0.0001

RVEF (EF units)

−0.2 ± 1.9

10.2 ± 2.3*^,†

13.5 ± 3.1*^,†

0.0008

Heart rate (BPM)

−14.2 ± 5.5^†

−15.4 ± 3.7^†

−19.9 ± 4.8^†

0.91

Mean arterial pressure (mm Hg)

−3.8 ± 3.8

−2.1 ± 4.7

−1.5 ± 4.1

0.99

Right atrial mean pressure (mm Hg)

0.2 ± 1.2

−0.1 ± 1.2

−2.2 ± 1.3

0.61

Pulmonary artery mean pressure (mm Hg)

−2.1 ± 2.1

0.3 ± 2.0

−9.9 ± 2.1*^,#,†

0.04

Pulmonary wedge mean pressure (mm Hg)

−1.3 ± 1.7

−0.2 ± 1.8

−8.4 ± 2.3^#,†

0.07

Cardiac index (l/min/m²)

0.02 ± 0.19

−0.14 ± 0.17

0.26 ± 0.20

0.62

Stroke volume index (ml/beat/m²)

7.5 ± 3.1^†

5.4 ± 2.3^†

11.1 ± 3.6^†

0.83

LV stroke work index (g-m/m²)

6.1 ± 2.8^§

3.3 ± 2.5

13.9 ± 4.2^†

0.41

Coronary sinus norepinephrine (pg/ml)

−258 ± 168

−149 ± 171

−206 ± 209

0.72

Peak Vo₂ (ml/kg/min)

1.0 ± 1.5

0.8 ± 1.4

1.3 ± 0.9

0.72