Figure 4

Perivascular spaces in Alzheimer’s disease white matter. Row A: The fine periarterial spaces are not normally visible at light microscopic level. Magnifications: left and center 100×; right 200×. Row B: The periarterial spaces appear to be slightly dilated. Magnifications: left 200×; center and right 100×. Rows C, D, and E demonstrate a series of severely distended perivascular spaces. The centrally located arteries apparently have a normal morphology. All captions were taken at 100×. All histological slides were stained with hematoxylin and eosin.