Histone Acetylation Modifiers in the Pathogenesis of Malignant Disease

Table 1 Human histone acetyltransferases

Family	Members	Alternate Symbols	Cytogenetic Position	Histone Preference (K: lysine specificity)				HAT type (A: nuclear, B: cytoplasmic)		References
Family	Members	Alternate Symbols	Cytogenetic Position	H2A	H2B	H3	H4	A	B	References
HAT	HAT1	—	2q31.2-q33.1	(++)			++	(+)	+	(29–31,55)
	HAT2	—	n.a.	K₅			K_5,12
GCN5	GCN5L1	—	12q13-q14			+++	+	+		(19,32–35)
	GCN5L2	—	17q21			K₁₄	K_8,16
P/CAF	P/CAF	—	3p24			++	++	+		(36–38,102)
						K₁₄	K₈
p300/CBP	p300	—	22q13.2	++	++	++	++	+		(36–38)
	CBP	—	16p13.3	K₅	K_5,12 _15,20	K_{14 18,23}	K_5,8> _12,16
p160	NCOA1	SRC-1	2p23
	NCOA2	GRIP-1 TIF2	8q13
	NCOA3	AIB1 RAC3 ACTR P/CIP TRAM-1	20q12	(+)	(+)	+	+	+		(40–43,104)
MYST	MOZ	—	8p11
	MORF	—	10q22.2	++		++	++	+		(44–51)
	HBO1	—	Xq21
	Tip60	—	11
TF_iiD		TAF2A
complex	TAF _II 250	CCG1 BA2R	Xq13			+++	+	+		(54)
hTF_IIIC90	hTF _III C90	—	NA			++		+		(52,53)

ISSN: 1528-3658