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Fig. 5 | Molecular Medicine

Fig. 5

From: Expression of the Proteinase Specialized in Bone Resorption, Cathepsin K, in Granulomatous Inflammation

Fig. 5

Immunohistochemical localization of cathepsin K in the E. granulosus hydatid cyst and in the bovine tissue surrounding it. The laminated layer of the cyst wall from E. granulosus-infected bovine lungs, and in some cases the surrounding host tissue, were paraffin-embedded. Slides were probed with rabbit antiserum against human cathepsin K (A, C, E, G) or normal rabbit serum (B, D, F, H). Sera were used at 1/200 (A–F) or 1/300 (G, H). The intact laminated layer separated from the host tissue (not subjected to antigen retrieval) is shown in (A, B). The inner part of the laminated layer (“L”) and the host tissue are shown in (C–H): the three layers of the host inflammatory infiltrate, namely epithelioid and giant cell layer (“E”), mononuclear and eosinophil infiltrate (“M”), and collagenous layer (“C”) are indicated. A multinucleated giant cell morphology is indicated in (G) with an arrowhead.

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