Table 1 Effects of chalcones on cultured T. b. brucei , purified trypanopain-Tb, and sheep cathepsin L
From: Chalcone, Acyl Hydrazide, and Related Amides Kill Cultured Trypanosoma brucei brucei
| ||||||
|---|---|---|---|---|---|---|
Compound | A | B | CLogP | T. b. brucei IC50 (µM) | Trypanopain Ki (µM)a | Cathepsin L Ki (µM)a |
MC153 |
|
| 3.295 | 4.79 | NIb | 12.11 ± 1.41 |
MC135 |
|
| 4.245 | 5.49 | NI | 9.55 ± 1.42 |
MC131b |
|
| 5.252 | 13.80 | 0.37 ± 0.06 | 7.16 ± 0.62 |
MC151 |
|
| 4.302 | 9.07 | 9.65 ± 0.91 | 9.48 ± 1.59 |
MC159 |
|
| 4.455 | 3.52 | NI | 4.57 ± 0.55 |
JD159 |
|
| 4.115 | 1.88 | 17.14 ± 1.76 | 6.95 ± 0.80 |
MC161 |
|
| 3.505 | 0.24 | NI | 40.72 ± 4.81 |
MC143 |
|
| 5.937 | 3.50 | 2.25 ± 0.29 | 2.66 ± 0.62 |
