From: Chalcone, Acyl Hydrazide, and Related Amides Kill Cultured Trypanosoma brucei brucei
| ||||||
---|---|---|---|---|---|---|
Compound | A | B | CLogP | T. b. brucei IC50 (µM) | Trypanopain Ki (µM)a | Cathepsin L Ki(µM)a |
MC24A24 |
|
| 5.276 | 28.56 | 0.61 ± 0.09 | 11.52 ± 1.38 |
MC24A4I |
|
| 5.746 | 11.82 | 1.06 ± 0.15 | 3.25 ± 0.62 |
MC23A24 |
|
| 5.276 | 10.00 | 0.26 ± 0.04 | 1.42 ± 0.14 |
MC08A27 |
|
| 5.498 | 13.50 | 0.66 ± 0.11 | 13.01 ± 1.49 |
BG31A02 |
|
| 4.721 | 1.82 | 0.50 ± 0.08 | 52.17 ± 3.43 |
BG21A11 |
|
| 3.203 | 4.44 | NIb | 61.07 ± 7.54 |
HH27A43 |
|
| 4.101 | 4.40 | 1.49 ± 0.24 | 16.09 ± 3.94 |
HH29A43 |
|
| 1.610 | 4.40 | NI | 20.49 ± 1.87 |
HH25A43 |
|
| 1.140 | 4.72 | NI | 49.70 ± 11.32 |