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Table 1 Plasma insulin, glucose, and PAI-1 levels after insulin treatment of different strains of obese insulin resistant mice

From: Insulin Continues to Induce Plasminogen Activator Inhibitor 1 Gene Expression in Insulin-Resistant Mice and Adipocytes

 

Plasma Insulin (ng/ml)

Plasma Glucose (mg/dL)

Plasma PAI-1 (ng/ml)

Straina

(−)

(+)

(−)

(+)

(−)

(+)

Lean

      

C57BL/6J

4.7 ± 1

39 ± 2.1

273 ± 77

76 ± 56

4.9 ± 3

18 ± 4

C57BLKs/J

5.5 ± 2

42 ± 3.2

140 ± 16

19 ± 3

7.6 ± 1.5

35 ± 1

Obese

      

C57BL/6J-ob/ob

35 ± 1.4

43.5 ± 2.1

199 ± 95

211 ± 48

19 ± 1.4

58 ± 8

C57BLKs/J-db/db

24.6 ± 7.5

52.1 ± 4.3

203 ± 4.9

148 ± 4.2

24 ± 4.9

103 ± 3.5

KK/Upj-A>y</J

34 ± 2.8

47.9 ± 4.5

401 ± 5.6

416 ± 16.2

25 ± 2.8

69 ± 12

C57BL/6J-tub

24 ± 13

46 ± 1.4

292 ± 7.7

107 ± 8.6

22 ± 7

49 ± 6

C57BLKs/-fat/fat

8.9 ± 1.5

54 ± 1.9

211 ± 5.6

25.5 ± 6.3

19 ± 1.6

53 ± 29

  1. aob/ob mice: 24−28 weeks old; all other strains: 12−14 weeks old.
  2. (—): before insulin treatment; (+): after insulin treatment. The (+) values for insulin and glucose are 3 hr after insulin treatment. The (+) values for PAI-1 are 6 hr after insulin treatment.
  3. n = 4 ± SD for all mice except the ob/ob, where n = 6 ± SD.
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Molecular Medicine

ISSN: 1528-3658