Fig. 2
From: Potent Induction of Apoptosis by β-Lapachone in Human Multiple Myeloma Cell Lines and Patient Cells
Differential effect of β-lapachone on proliferation of multiple myeloma (MM) cells vs. normal PBMC. Proliferation of MM cells, quiescent peripheral blood mononuclear cells (PBMC) and proliferative PBMC cultured in the absence of or with β-lapachone (0.5, 2, 4, 8, or 20 µM) for 24 h was measured by MTT assay. Cells used include in: (A) ARH-77, MM.1S and HSSultan (sensitive MM cell lines), (B) MM.As (MM patient cell), (C) MM.1R, DOX.40, MR.20 and LR5 (resistant MM cell lines), (D) quiescent PBMC, (E) proliferating PBMCs (generated by 72 h incubation with PHA at 2 µg/ml). In the absence of β-lapachone, cells were treated with an equal volume of dimethyl sulfoxide.