Blood glucose values for Shb-transgenic and control CBA mice of both sexes after multiple injections of streptozotocin. (A) Mice of both groups were injected with streptozotocin (SZ) or saline and the blood glucose levels were determined immediately before the start of injections and 1, 2, and 3 weeks thereafter. Data for mean ± SEM are given for 8–11 mice. *p < 0.05 when tested with an unpaired Students’ t-test against the corresponding CBA-SZ value. (B) Role of gender in the development of hyperglycemia in Shb-transgenic and CBA control mice after multiple streptozotocin injections. Blood glucose determinations were performed as in A. Data for mean ± SEM are given. *p < 0.05 when tested against the corresponding value for CBA-male mice using an unpaired Students’ t-test. Male CBA, n = 4; female CBA, n = 7; male Shb, n = 6; female Shb, n = 4.