| β-Cell Area (%) | β-Cell Area (%) | Labeling Index (%) |
---|
|
Day 1 Neonatally
|
6 Months of Age
|
3 Months of Age
|
---|
CBA | 0.79 ± 0.18(n = 5) | 0.76 ± 0.16(n = 4) | 2.38 ± 0.76(n = 3) |
Shb | 1.58 ± 0.26*(n = 4) | 1.34 ± 0.16*(n = 4) | 2.59 ± 0.71(n = 3) |
- β-cell area is the percentage of insulin-positive area relative to that of total pancreas area determined at day 1 neonatally or 6 months of age for CBA control or Shb transgenic mice. The labeling index values are percent insulin-positive cells with nuclei that have incorporated [3H]-thymidine of animals injected with the isotope at 3 months of age.
- *p < 0.05 using an unpaired Student’s t-test when compared with CBA control.