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Fig. 6 | Molecular Medicine

Fig. 6

From: An Essential Role for Macrophage Migration Inhibitory Factor (MIF) in Angiogenesis and the Growth of a Murine Lymphoma

Fig. 6

Anti-MIF inhibits microvascular endothelial cell proliferation in vitro. Endothelial cells were treated with anti-MIF mAb, control IgG, m Ab, or PBS for 20 hr. Cells were pulsed with [3H]thymidine for the last 16 hr of incubation and proliferation was analyzed by liquid scintillation counting. Data are expressed as mean ± SD (n = 4) and are representative of one experiment that was performed three times (*p < 0.01). Direct cell counts showed (cells/well): PBS control: 8512 ± 775; IgG1 (25 µg/ml): 9186 ± 1334, (50 µg/ml): 8965 ± 980, (100 µg/ml): 9319 ± 1457, (200 µg/ml): 8830 ± 1876; anti-MIF mAb (25 µg/ml): 8068 ± 773, (50 µg/ml): 7718 ± 1194, (100 µg/ml): 5513 ± 637*, (200 µg/ml): 4107 ± 1173* (*p < 0.02).

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