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Fig. 3 | Molecular Medicine

Fig. 3

From: Peptidomimetic Fluoromethylketone Rescues Mice from Lethal Endotoxic Shock

Fig. 3

Effect of peptidomimetic fluoromethylketones on serum cytokines. Mice were challenged ip with vehicle 1 (−; see Materials and Methods) or LPS (+; 500 µg in vehicle 1), followed 1 hr later by peptidomimetic fluoromethylketones (10 mg/kg, except for C, where doses were varied as shown, given in vehicle 2; see Materials and Methods) or vehicle 2 alone (veh.). Mice were sacrificed at the following times after LPS challenge for serum cytokine measurements: 1.5 hr, TNF (H); 3 hr, IL-1β (A), IL-1α (B), IL-1ra (D), IL-18 (F), SAA (E); 5 hr, IFN-γ (G), n = mice per group, pooled from the following number of independent experiments: (A), 3; (B), 3; (D), 3; (E), 2; (F), 3; (G), 2; (H), 2. Asterisks denote statistical significance (p < 0.05) compared to LPS-challenged, vehicle-treated mice. (C) Dose-response effect of IDN 1529 on LPS-induced elevation in serum IL-1β; means ± SEM for 8 mice per time point.

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