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Fig. 6 | Molecular Medicine

Fig. 6

From: Peptidomimetic Fluoromethylketone Rescues Mice from Lethal Endotoxic Shock

Fig. 6

Effect of treatment with peptidomimetic fluoromethylketones on caspase 3-like activity in organs of mice. Mice were challenged ip with vehicle 1 (−; see Materials and Methods) or LPS (+; 500 µg in vehicle 1), followed 1 hr later by caspase inhibitor (10 mg/kg in vehicle 2; see Materials and Methods) or vehicle 2 alone (veh.). Mice were sacrificed 11 hr following LPS challenge and organ homogenates incubated with DEVD-AMC. (A) liver; (B) intestine; (C) kidney; (D) lung. *, statistically significant differences relative to LPS-challenged, vehicle-treated mice. †, significant difference (p < 0.05) relative to mice not given LPS. n = number of mice per group. Results are pooled from three independent experiments.

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