Skip to main content

Table 1 Survival time of heterotopic cardiac xenografts of transgenic rat hearts (hemizygous DAF+/−or homozygous DAF+/+) transplanted into cynomolgus recipients

From: Protection Against Hyperacute Xenograft Rejection of Transgenic Rat Hearts Expressing Human Decay Accelerating Factor (DAF) Transplanted into Primates

 

Rat donor

 

Wild type

Hemizygous (DAF+/−)

Homozygous (DAF+/+)

Survival time

5.5 ± 1.4 min

15.2 ± 7.4 min*

>1.5 hr**a

  

(10, 11, 12, 28 min)

>4.5 hr**a

 

(n = 10)

(n = 4)

(n = 2)

  1. Rat hearts were grafted on femoral vessels bilaterally for hemizygous and homozygous rats. Wild-type heart survival has been previously reported (19).
  2. aAnalyses of the last time points for each graft showing beating hearts (next analysis at 24 hr showed rejection).
  3. *p < 0.05 for transplants from hemizygous DAF rats versus wild-type rats.
  4. **p < 0.05 for transplants from homozygous DAF rats versus wild-type rats or hemizygous DAF rats.