| Rat donor |
---|
| Wild type | Hemizygous (DAF+/−) | Homozygous (DAF+/+) |
---|
Survival time | 5.5 ± 1.4 min | 15.2 ± 7.4 min* | >1.5 hr**a |
| | (10, 11, 12, 28 min) | >4.5 hr**a |
| (n = 10) | (n = 4) | (n = 2) |
- Rat hearts were grafted on femoral vessels bilaterally for hemizygous and homozygous rats. Wild-type heart survival has been previously reported (19).
- aAnalyses of the last time points for each graft showing beating hearts (next analysis at 24 hr showed rejection).
- *p < 0.05 for transplants from hemizygous DAF rats versus wild-type rats.
- **p < 0.05 for transplants from homozygous DAF rats versus wild-type rats or hemizygous DAF rats.