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Fig. 5 | Molecular Medicine

Fig. 5

From: Butyrate Switches the Pattern of Chemokine Secretion by Intestinal Epithelial Cells through Histone Acetylation

Fig. 5

Effect of butyrate and trichostatin-A in the induction of histone acetylation and chemokine secretion by Caco-2 cells. Both butyrate and trichostatin-A increased the acetylation of histones. IL-8 secretion was simultaneously increased (p < 0.0001) and MCP-1 production decreased in Caco-2 cells stimulated with IL-1β (p < 0.001). Trichostatin-A, a specific histone deacetylase inhibitor, acted in a manner similar to that of butyrate when given at concentrations that produced a comparable change in histone acetylation. Bars represent standard deviations of three different wells for each point. The data are representative of three experiments.

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