Phase contrast images showing dissociated E15.5 mouse pancreas cells cultured with and without BMP-6 (10 ng/ml) and laminin-1 (160 µg/ml). (A) Day 1 in the presence of both laminin-1 and BMP-6. (B, C, D) Day 6: BMP-6 induced pancreatic cell colony formation in the presence of laminin-1. Without BMP-6, fewer colonies formed in the presence of laminin-1 only. BMP-6 alone failed to promote colony formation in the absence of laminin-1.