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Fig. 4 | Molecular Medicine

Fig. 4

From: Anx7 Is Required for Nutritional Control of Gene Expression in Mouse Pancreatic Islets of Langerhans

Fig. 4

Classification of the effect of knocking out Anx7 on the response of gene expression to fasting stress sorted by stress effect. The effects of the two experimental conditions, Anx7(+/−) and the stress of fasting are depicted in HELP diagrams for the top 5% of genes most affected by fasting. The HELP diagrams are sorted according to the classes of the response to Anx7 knockout: (A) Anx7 knockout affects only gene expression in the fasting state (vertical vectors); (B) Anx7 knockout affects only gene expression in the fed state (horizontal vectors); (C) vectors parallel to the main diagonal; and (D) Anx7 knockout causes gene expression in both states to become equal (vectors pointing toward the main diagonal). Red vectors denote increased expression and blue vectors denote decreased expression in the fasting state.

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