Table 3 Effect of fasting stress and Anx7 knockout on gene expression in mouse pancreatic islets

HR21SP

DNA double-strand break repair RAD21 homolog; HR21SP; PW29

0.16

4.82

0.77

0.65

31.0(↑)

1.2(↓)

FST

Follistatin precursor (FST); activin-binding protein

0.19

2.91

0.79

0.93

15.5(↑)

1.2(↑)

mHR23A

RAD23 UV excision repair protein homolog A (mHR23A; RAD23A)

0.90

8.95

1.04

0.83

10.0(↑)

1.3(↓)

mGCM1

Glial cells missing gene homolog (mGCM1)

1.67

0.12

1.13

0.77

14.2(↓)

1.5(↓)

GSTT1

Gluthathione S-transferase theta 1 (GST theta 1; GSTT1)

0.09

1.40

0.72

1.24

15.3(↑)

1.7(↑)

ELF1

ets-Related transcription factor; E74-like factor 1 (ELF1)

0.84

0.11

0.89

0.94

7.9(↓)

1.1(↑)

SCYB9

Small inducible cytokine B subfamily member 9 (SCYB9); monoking induced by gamma interferon (MIG)

0.29

2.34

0.86

0.86

8.0(↑)

1.0(↓)

MLH1

MLH1 DNA mismatch repair protein; MutL homolog

0.68

3.92

0.85

0.64

5.8(↑)

1.3(↓)

CRABP2

Cellular retinioc acid-binding protein II (CRABO-II;CRABP2)

0.89

0.11

0.87

0.78

8.4(↓)

1.1(↓)

FGF9

Fibroblast growth factor 9

0.31

2.76

0.75

0.99

9.0(↑)

1.3(↑)

TSN

Translin (TSN)

1.15

7.52

1.09

1.07

6.5(↑)

1.0(↓)

GDNF

Glial cell line-derived neurotropic factor precursor (GDNF)

0.43

2.41

0.88

0.74

5.6(↑)

1.2(↓)

ITGAM

Cell-surface glycoprotein MAC-1 alpha subunit precursor; CR-3 alpha subunit; CD11B antigen; leukocyte adhesion receptor MO1; integrin alpha-M (ITGAM)

0.21

1.91

0.64

0.90

9.3(↑)

1.4(↑)

TFDP1

Transcription factor E2F dimerization partner 1 (TFDP1); DRTF1 polypeptide 1

1.91

0.22

1.32

0.92

8.6(↓)

1.4(↓)

GADD153

Growth arrest and DNA damage-inducible protein 153 (GADD153); DNA damage-inducible transcript 3 (DDIT3); C/EBP-homologous protein (CHOP)

0.21

3.12

0.72

1.89

14.7(↑)

2.6(↑)

SPI3

Serine proteinase inhibitor 3 (SPI3)

1.44

0.24

1.01

0.91

6.1(↓)

1.1(↓)

GPIA

Platelet membrane glycoprotein IA precursor (GPIA); integrin alpha 2 (ITGA); collagen receptor; VLA2 alpha subunit; CD49B antigen

0.56

0.08

0.80

0.63

6.8(↓)

1.3(↓)

XPG

Xeroderma pigmentosum group G complementing protein (XPG); X-ray repair-complementing defective repair in Chinese hamster cells 5 (XRCC5)

0.75

3.89

0.96

0.94

5.2(↑)

1.0(↓)

PML

Promyelocytic leukemia gene (PML)

0.80

0.14

0.94

0.80

5.7(↓)

1.2(↓)

hHR23B

UV excision repair protein RAD23 homolog B (hHR23B); xeroderma pigmentosum group C repair-complementing complex 58-kDa protein (XPC repair-complementing complex 58-kDa protein)

4.35

17.53

1.97

1.69

4.0(↑)

1.2(↓)

NFIA

Nuclear factor I/A (NFIA); NFIB

1.68

0.35

1.05

1.01

4.8(↓)

1.0(↓)

DAD1

Defender against cell death 1 protein (DAD1)

0.17

1.12

0.71

1.06

6.4(↑)

1.5(↑)

PAX6

Paired box protein 6 (PAX6); small eye protein (SEY)

0.77

0.20

0.97

1.07

3.9(↓)

1.1(↑)

TEK

Endothelial-specific receptor tyrosine kinase (TEK); tunica interna endothelial cell kinase 2 (TIE2); adhesion structures-linked tyrosine kinase (HYK); angiopoietin 1 receptor precursor

1.32

0.28

1.09

1.00

4.7(↓)

1.1(↓)

GRIN2

Glutamate receptor subunit epsilon 2 precursor (GRIN2); N-methyl d-aspartate receptor subtype 2B (NMDAR2B; NR2B)

0.21

0.86

0.63

0.68

4.2(↑)

1.1(↑)

T-β2

Transducin beta-2 subunit

0.71

0.20

0.79

0.81

3.6(↓)

1.0(↑)

A-RAF

A-raf proto-oncogene

1.97

0.38

1.26

0.85

5.2(↓)

1.5(↓)

GATA3

GATA-binding protein 3 (GATA3)

2.40

0.46

1.48

0.97

5.2(↓)

1.5(↓)

TDAG51

T-cell death-associated gene 51 (TDAG51)

0.18

0.74

0.85

1.04

4.1(↑)

1.2(↑)

5HT1E-β

5-Hydroxytryptamine receptor 1E receptor beta (5HT1E-beta; HTR1E-beta); serotonin receptor

0.26

0.91

0.72

0.78

3.5(↑)

1.1(↑)

SMBP2

DNA-binding protein SMBP2

1.81

0.40

1.53

1.01

4.5(↓)

1.5(↓)

NCAD

Cadherin 2 (CDH2); neural-cadherin precursor (N-cadherin; NCAD)

0.48

2.61

0.68

1.25

5.4(↑)

1.8(↑)

TNFR2

Tumor necrosis factor receptor superfamily member 1B2 (TNFRSF1B2); tumor necrosis factor receptor 2 precursor (TNFR2)

0.45

2.31

0.89

1.60

5.1(↑)

1.8(↑)

SLAP

SLAP; src-like adapter protein; Eck receptor tyrosine kinase-associated

0.12

0.34

0.72

0.79

2.8(↑)

1.1(↑)

PPG

Preproglucagon

1.67

1.99

2.74

1.31

1.2(↑)

2.1(↓)

AA3R

Adenosine A3 receptor

0.29

0.56

0.82

0.71

1.9(↑)

1.1(↓)

HGF

Hepatocyte growth factor (HGF)

0.48

0.22

0.80

0.80

2.2(↓)

1.0(↑)

PTP

Protein tyrosine phosphatase

0.38

0.62

1.02

0.80

1.6(↑)

1.3(↓)

SIM2

Single-minded 2 (SIM2)

5.88

24.21

2.55

5.57

4.1(↑)

2.2(↑)

FYN

Fyn proto-oncogene

0.25

0.49

0.80

0.87

2.0(↑)

1.1(↑)

MGST1

Microsomal glutathione S-transferase (MGST1; GST12)

0.81

2.65

0.92

1.75

3.2(↑)

1.9(↑)

EPHB2

Eph receptor B2

0.24

0.35

0.82

0.74

1.5(↑)

1.1(↓)

VEGF

Vascular endothelial growth factor precursor (VEGF); vascular permeability factor (VPF)

0.29

0.61

0.96

1.24

2.1(↑)

1.3(↑)

CCN2

G2/mitotic-specific cyclin B1(CCNB1;CYCBI);CCN2

2.82

0.92

1.49

0.77

3.1(↓)

1.9(↓)

KRT18

Type I cytoskeletal keratin 18 (KRT1-18; KRT18); cytokeratin 18; cytokeratin endo B; keratin D (KERD)

5.09

6.80

2.41

5.08

1.3(↑)

2.1(↑)

GRA

Glucocorticoid receptor form A

0.12

0.22

0.62

0.76

1.9(↑)

1.2(↑)

HSP84

Heat shock 84-kDa protein (HSP84); HSP90 beta HSPCB; tumor-specific transplantation 84-kDA antigen (TSTA)

1.09

1.32

1.01

1.70

1.2(↑)

1.7(↑)

SCYB2

Small inducible cytokine B2 (SCYB2); macrophage inflamatory protein 2 alpha (MIP2-alpha; MIP2A)

1.40

1.80

1.12

2.02

1.3(↑)

1.8(↑)

SP2

U2 small nuclear ribonucleoprotein auxiliary factor 35-kDa subunit-related protein 1 (U2AF1-RSI); SP2

6.16

8.21

2.86

5.19

1.3(↑)

1.8(↑)

CCNA1

G2/mitotic-specific cyclin A1 (CCNA1)

16.95

9.52

6.35

2.63

1.8(↓)

2.4(↓)

BRCA2

Breast cancer type 2 susceptibility protein (BRCA2)

21.64

19.95

6.50

4.52

1.1(↓)

1.4(↓)

UBE2B

Ubiquitin-conjugating enzyme E2 17-kDa(UBE2B); ubiquitin-protein ligase; ubiquitin carrier protein; HR6B

6.98

11.35

2.09

2.59

1.6(↑)

1.2(↑)

CRP3

CCAAT/enhancer-binding protein delta (C/EBP delta; CEBPD); C/EBP-related protein 3 (CRP3)

2.60

3.61

1.64

2.92

1.4(↑)

1.8(↑)

OSM

Oncostatin M (OSM)

5.31

3.52

3.03

1.58

1.5(↓)

1.9(↓)

BCLW

B-cell lymphoma protein W(BCLW); BCL2-like protein 2 (BCL2L2)

0.27

0.16

0.83

0.62

1.6(↓)

1.3(↓)

GRase

Glutathione reductase (GRase; GSR; GR)

0.29

0.22

0.82

0.76

1.3(↓)

1.1(↓)

APC

adenomatous polyposis coli protein (APC)

6.49

3.53

2.76

1.53

1.6(↓)

1.8(↓)

MADH1

Mothers against decapentaplegic homolog 1 (MADH1; mSMAD1); TGF-beta signaling protein 1(BSP1)

5.64

3.73

2.52

1.52

1.5(↓)

1.7(↓)

GPI

Glucose-6-phosphate isomerase (GPI); phosphoglucose isomerase (PGI); phosphohexoseisomerase(PHI); neuroleukin (NLK)

33.89

22.65

8.75

5.39

1.5(↓)

1.6(↓)

ATF3

Activating transcription factor 3 (ATF3); LRG-21

0.34

0.66

0.75

1.39

1.9(↑)

1.9(↑)

APOJ

Clusterin precursor (CLU); clustrin; apolipoprotein J (APOJ); sulfated glycoprotein 2 (SGP2; mSGP2)

1.58

2.74

1.12

2.02

1.7(↑)

1.8(↑)