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Table 3 Effect of fasting stress and Anx7 knockout on gene expression in mouse pancreatic islets

From: Anx7 Is Required for Nutritional Control of Gene Expression in Mouse Pancreatic Islets of Langerhans

   Expression Levels Ratio (Fast/Fed), Fold Increase (↑) or Decrease (↓)
Symbol Gene Name Con, Fed Con, Fasting K/O, Fed K/O, Fasting Con K/O
HR21SP DNA double-strand break repair RAD21 homolog; HR21SP; PW29 0.16 4.82 0.77 0.65 31.0(↑) 1.2(↓)
FST Follistatin precursor (FST); activin-binding protein 0.19 2.91 0.79 0.93 15.5(↑) 1.2(↑)
mHR23A RAD23 UV excision repair protein homolog A (mHR23A; RAD23A) 0.90 8.95 1.04 0.83 10.0(↑) 1.3(↓)
mGCM1 Glial cells missing gene homolog (mGCM1) 1.67 0.12 1.13 0.77 14.2(↓) 1.5(↓)
GSTT1 Gluthathione S-transferase theta 1 (GST theta 1; GSTT1) 0.09 1.40 0.72 1.24 15.3(↑) 1.7(↑)
ELF1 ets-Related transcription factor; E74-like factor 1 (ELF1) 0.84 0.11 0.89 0.94 7.9(↓) 1.1(↑)
SCYB9 Small inducible cytokine B subfamily member 9 (SCYB9); monoking induced by gamma interferon (MIG) 0.29 2.34 0.86 0.86 8.0(↑) 1.0(↓)
MLH1 MLH1 DNA mismatch repair protein; MutL homolog 0.68 3.92 0.85 0.64 5.8(↑) 1.3(↓)
CRABP2 Cellular retinioc acid-binding protein II (CRABO-II;CRABP2) 0.89 0.11 0.87 0.78 8.4(↓) 1.1(↓)
FGF9 Fibroblast growth factor 9 0.31 2.76 0.75 0.99 9.0(↑) 1.3(↑)
TSN Translin (TSN) 1.15 7.52 1.09 1.07 6.5(↑) 1.0(↓)
GDNF Glial cell line-derived neurotropic factor precursor (GDNF) 0.43 2.41 0.88 0.74 5.6(↑) 1.2(↓)
ITGAM Cell-surface glycoprotein MAC-1 alpha subunit precursor; CR-3 alpha subunit; CD11B antigen; leukocyte adhesion receptor MO1; integrin alpha-M (ITGAM) 0.21 1.91 0.64 0.90 9.3(↑) 1.4(↑)
TFDP1 Transcription factor E2F dimerization partner 1 (TFDP1); DRTF1 polypeptide 1 1.91 0.22 1.32 0.92 8.6(↓) 1.4(↓)
GADD153 Growth arrest and DNA damage-inducible protein 153 (GADD153); DNA damage-inducible transcript 3 (DDIT3); C/EBP-homologous protein (CHOP) 0.21 3.12 0.72 1.89 14.7(↑) 2.6(↑)
SPI3 Serine proteinase inhibitor 3 (SPI3) 1.44 0.24 1.01 0.91 6.1(↓) 1.1(↓)
GPIA Platelet membrane glycoprotein IA precursor (GPIA); integrin alpha 2 (ITGA); collagen receptor; VLA2 alpha subunit; CD49B antigen 0.56 0.08 0.80 0.63 6.8(↓) 1.3(↓)
XPG Xeroderma pigmentosum group G complementing protein (XPG); X-ray repair-complementing defective repair in Chinese hamster cells 5 (XRCC5) 0.75 3.89 0.96 0.94 5.2(↑) 1.0(↓)
PML Promyelocytic leukemia gene (PML) 0.80 0.14 0.94 0.80 5.7(↓) 1.2(↓)
hHR23B UV excision repair protein RAD23 homolog B (hHR23B); xeroderma pigmentosum group C repair-complementing complex 58-kDa protein (XPC repair-complementing complex 58-kDa protein) 4.35 17.53 1.97 1.69 4.0(↑) 1.2(↓)
NFIA Nuclear factor I/A (NFIA); NFIB 1.68 0.35 1.05 1.01 4.8(↓) 1.0(↓)
DAD1 Defender against cell death 1 protein (DAD1) 0.17 1.12 0.71 1.06 6.4(↑) 1.5(↑)
PAX6 Paired box protein 6 (PAX6); small eye protein (SEY) 0.77 0.20 0.97 1.07 3.9(↓) 1.1(↑)
TEK Endothelial-specific receptor tyrosine kinase (TEK); tunica interna endothelial cell kinase 2 (TIE2); adhesion structures-linked tyrosine kinase (HYK); angiopoietin 1 receptor precursor 1.32 0.28 1.09 1.00 4.7(↓) 1.1(↓)
GRIN2 Glutamate receptor subunit epsilon 2 precursor (GRIN2); N-methyl d-aspartate receptor subtype 2B (NMDAR2B; NR2B) 0.21 0.86 0.63 0.68 4.2(↑) 1.1(↑)
T-β2 Transducin beta-2 subunit 0.71 0.20 0.79 0.81 3.6(↓) 1.0(↑)
A-RAF A-raf proto-oncogene 1.97 0.38 1.26 0.85 5.2(↓) 1.5(↓)
GATA3 GATA-binding protein 3 (GATA3) 2.40 0.46 1.48 0.97 5.2(↓) 1.5(↓)
TDAG51 T-cell death-associated gene 51 (TDAG51) 0.18 0.74 0.85 1.04 4.1(↑) 1.2(↑)
5HT1E-β 5-Hydroxytryptamine receptor 1E receptor beta (5HT1E-beta; HTR1E-beta); serotonin receptor 0.26 0.91 0.72 0.78 3.5(↑) 1.1(↑)
SMBP2 DNA-binding protein SMBP2 1.81 0.40 1.53 1.01 4.5(↓) 1.5(↓)
NCAD Cadherin 2 (CDH2); neural-cadherin precursor (N-cadherin; NCAD) 0.48 2.61 0.68 1.25 5.4(↑) 1.8(↑)
TNFR2 Tumor necrosis factor receptor superfamily member 1B2 (TNFRSF1B2); tumor necrosis factor receptor 2 precursor (TNFR2) 0.45 2.31 0.89 1.60 5.1(↑) 1.8(↑)
SLAP SLAP; src-like adapter protein; Eck receptor tyrosine kinase-associated 0.12 0.34 0.72 0.79 2.8(↑) 1.1(↑)
PPG Preproglucagon 1.67 1.99 2.74 1.31 1.2(↑) 2.1(↓)
AA3R Adenosine A3 receptor 0.29 0.56 0.82 0.71 1.9(↑) 1.1(↓)
HGF Hepatocyte growth factor (HGF) 0.48 0.22 0.80 0.80 2.2(↓) 1.0(↑)
PTP Protein tyrosine phosphatase 0.38 0.62 1.02 0.80 1.6(↑) 1.3(↓)
SIM2 Single-minded 2 (SIM2) 5.88 24.21 2.55 5.57 4.1(↑) 2.2(↑)
FYN Fyn proto-oncogene 0.25 0.49 0.80 0.87 2.0(↑) 1.1(↑)
MGST1 Microsomal glutathione S-transferase (MGST1; GST12) 0.81 2.65 0.92 1.75 3.2(↑) 1.9(↑)
EPHB2 Eph receptor B2 0.24 0.35 0.82 0.74 1.5(↑) 1.1(↓)
VEGF Vascular endothelial growth factor precursor (VEGF); vascular permeability factor (VPF) 0.29 0.61 0.96 1.24 2.1(↑) 1.3(↑)
CCN2 G2/mitotic-specific cyclin B1(CCNB1;CYCBI);CCN2 2.82 0.92 1.49 0.77 3.1(↓) 1.9(↓)
KRT18 Type I cytoskeletal keratin 18 (KRT1-18; KRT18); cytokeratin 18; cytokeratin endo B; keratin D (KERD) 5.09 6.80 2.41 5.08 1.3(↑) 2.1(↑)
GRA Glucocorticoid receptor form A 0.12 0.22 0.62 0.76 1.9(↑) 1.2(↑)
HSP84 Heat shock 84-kDa protein (HSP84); HSP90 beta HSPCB; tumor-specific transplantation 84-kDA antigen (TSTA) 1.09 1.32 1.01 1.70 1.2(↑) 1.7(↑)
SCYB2 Small inducible cytokine B2 (SCYB2); macrophage inflamatory protein 2 alpha (MIP2-alpha; MIP2A) 1.40 1.80 1.12 2.02 1.3(↑) 1.8(↑)
SP2 U2 small nuclear ribonucleoprotein auxiliary factor 35-kDa subunit-related protein 1 (U2AF1-RSI); SP2 6.16 8.21 2.86 5.19 1.3(↑) 1.8(↑)
CCNA1 G2/mitotic-specific cyclin A1 (CCNA1) 16.95 9.52 6.35 2.63 1.8(↓) 2.4(↓)
BRCA2 Breast cancer type 2 susceptibility protein (BRCA2) 21.64 19.95 6.50 4.52 1.1(↓) 1.4(↓)
UBE2B Ubiquitin-conjugating enzyme E2 17-kDa(UBE2B); ubiquitin-protein ligase; ubiquitin carrier protein; HR6B 6.98 11.35 2.09 2.59 1.6(↑) 1.2(↑)
CRP3 CCAAT/enhancer-binding protein delta (C/EBP delta; CEBPD); C/EBP-related protein 3 (CRP3) 2.60 3.61 1.64 2.92 1.4(↑) 1.8(↑)
OSM Oncostatin M (OSM) 5.31 3.52 3.03 1.58 1.5(↓) 1.9(↓)
BCLW B-cell lymphoma protein W(BCLW); BCL2-like protein 2 (BCL2L2) 0.27 0.16 0.83 0.62 1.6(↓) 1.3(↓)
GRase Glutathione reductase (GRase; GSR; GR) 0.29 0.22 0.82 0.76 1.3(↓) 1.1(↓)
APC adenomatous polyposis coli protein (APC) 6.49 3.53 2.76 1.53 1.6(↓) 1.8(↓)
MADH1 Mothers against decapentaplegic homolog 1 (MADH1; mSMAD1); TGF-beta signaling protein 1(BSP1) 5.64 3.73 2.52 1.52 1.5(↓) 1.7(↓)
GPI Glucose-6-phosphate isomerase (GPI); phosphoglucose isomerase (PGI); phosphohexoseisomerase(PHI); neuroleukin (NLK) 33.89 22.65 8.75 5.39 1.5(↓) 1.6(↓)
ATF3 Activating transcription factor 3 (ATF3); LRG-21 0.34 0.66 0.75 1.39 1.9(↑) 1.9(↑)
APOJ Clusterin precursor (CLU); clustrin; apolipoprotein J (APOJ); sulfated glycoprotein 2 (SGP2; mSGP2) 1.58 2.74 1.12 2.02 1.7(↑) 1.8(↑)
  1. Effect of the fasting vs. fed paradigm on significantly and differentially affected expression of genes associated with development and differentiation of islets in the control and Anx7(+/−) knockout mouse.