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Table 3 Frequencies of the HLA class I specificities analyzed in selecting the putative CTL epitopes in the Gag protein (data from XII IHW)

From: Computer-Based Design of an HLA-Haplotype and HIV-Clade Independent Cytotoxic T-Lymphocyte (CTL) Assay for Monitoring HIV-Specific Immunity

HLA Specificity*

Populations

Caucasian

North African

African

Asian

Amerind

A1

14.3

3.6

4.7

2.2

4.2

A2

27.8

13.6

16.9

25.1

31.5

A3

12.6

5.9

6.1

1.1

2.6

A24

8.9

5.4

3.4

24.3

18.0

A31

2.5

0.8

2.6

5.1

24.2

A33

1.7

8.0

8.2

7.8

5.1

A68

4.1

2.4

8.1

1.2

0

B7

9.2

4.2

7.4

8.6

2.7

B8

8.7

3.4

4.9

0.1

2.6

B14

3.7

3.6

2.8

0.4

3.2

B15

3.3

5.2

9.3

10.2

10.8

B27

3.8

1.7

1.2

1.8

1.0

B35

9.7

4.8

8.9

6.5

25.8

B37

1.4

0.8

0.7

0.7

0

B38

2.8

0.8

0.2

2.2

2.1

B39

1.9

4.5

1.2

3.6

17.9

B40

0.8

1.2

0.3

6.3

12

B44

12.1

5.1

5.8

5.4

2.2

B51

6.5

2.5

2.8

5.3

9.5

B52

1.6

2.5

2.7

5.8

2.4

B58

1.5

6.3

8.5

1.8

0.2

B60

3.4

0

0.4

4.4

1.5

B61

1.6

0.8

0.3

6.2

8.0

B62

4.7

1.8

0.8

9.2

5.3

Cw3

6.3

2.8

1.3

12.2

1.1

Cw4

12.3

11.8

16.5

5.7

18.9

Cw6

9.0

8.0

10.5

3.9

4.6

Cw7

23.3

13.7

17.4

17.0

30.6

Overall

96%

91%

93%

95%

98%

Specificity†

     
  1. *Data summarize the frequencies of the HLA class I alleles included in the serologic specificities reported and used for analyzing the putative CTL epitopes of GAG protein.
  2. †Overall frequency of the HLA class I haplotypes in the different populations including the serologic specificities analyzed.
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Molecular Medicine

ISSN: 1528-3658