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Fig. 1 | Molecular Medicine

Fig. 1

From: Visualization of Irreparable Ischemic Damage in Brain by Selective Labeling of Double-Strand Blunt-Ended DNA Breaks

Fig. 1

Schematics of in situ ligation for selective detection of blunt-ended DNA breaks in tissue sections. The blunt-ended probe, shown as a double-strand DNA fragment carrying a single fluorophore, is attached to the end of a blunt-ended DNA break in tissue section using T4 DNA ligase. The detected break possesses 5′ phosphate, needed for the ligation reaction.

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Molecular Medicine

ISSN: 1528-3658