TY - JOUR AU - Gibbs, J. B. AU - Oliff, A. PY - 1997 DA - 1997// TI - The potential of farnesyltransferase inhibitors as cancer chemotherapeutics JO - Annu. Rev. Pharmacol. Toxicol. VL - 37 UR - https://doi.org/10.1146/annurev.pharmtox.37.1.143 DO - 10.1146/annurev.pharmtox.37.1.143 ID - Gibbs1997 ER - TY - JOUR AU - Cox, A. D. AU - Der, C. J. PY - 1997 DA - 1997// TI - Farnesyltransferase inhibitors and cancer treatment: targeting simply Ras? JO - Biochim. Biophys. Acta VL - 1333 ID - Cox1997 ER - TY - JOUR AU - James, G. L. AU - Goldstein, J. L. AU - Brown, M. S. PY - 1993 DA - 1993// TI - Benzodiazepine peptidomimetics: potent inhibitors of Ras farnesylation in animal cells JO - Science VL - 260 UR - https://doi.org/10.1126/science.8316834 DO - 10.1126/science.8316834 ID - James1993 ER - TY - JOUR AU - Manne, V. AU - Yan, N. AU - Carboni, J. M. PY - 1995 DA - 1995// TI - Bisubstrate inhibitors of farnesyltransferase: a novel class of specific inhibitors of ras transformed cells JO - Oncogene VL - 10 ID - Manne1995 ER - TY - JOUR AU - Nagasu, T. AU - Yoshimatsu, K. AU - Rowell, C. AU - Lewis, M. D. AU - Garcia, A. M. PY - 1995 DA - 1995// TI - Inhibition of human tumor xenograft growth by treatment with the farnesyl protein transferase inhibitor B956 JO - Cancer Res. VL - 55 ID - Nagasu1995 ER - TY - JOUR AU - Prendergast, G. C. AU - Davide, J. P. AU - deSolms, S. J. PY - 1994 DA - 1994// TI - Farnesyltransferase inhibition causes morphological reversion of rastransformed cells by a complex mechanism that involves regulation of the actin cytoskeleton NE JO - Mol. Cell. Biol. VL - 14 UR - https://doi.org/10.1128/MCB.14.6.4193 DO - 10.1128/MCB.14.6.4193 ID - Prendergast1994 ER - TY - JOUR AU - Sepp-Lorenzino, L. AU - Ma, Z. AU - Rands, E. PY - 1995 DA - 1995// TI - A peptidomimetic inhibitor of farnesyl:protein transferase blocks the anchorage-dependent and -independent growth of human tumor cell lines JO - Cancer Res VL - 55 ID - Sepp-Lorenzino1995 ER - TY - JOUR AU - Sun, J. AU - Qian, Y. AU - Hamilton, A. D. AU - Sebti, S. M. PY - 1995 DA - 1995// TI - Ras CAAX peptidomimetic FTI 276 selectively blocks tumor growth in nude mice of a human lung carcinoma with K-Ras mutation and p53 deletion JO - Cancer Res. VL - 55 ID - Sun1995 ER - TY - JOUR AU - Adamson, P. AU - Marshall, C. J. AU - Hall, A. AU - Tilbrook, P. A. PY - 1992 DA - 1992// TI - Posttranslational modifications of p21rho proteins JO - J. Biol. Chem. VL - 267 ID - Adamson1992 ER - TY - JOUR AU - Du, W. AU - Lebowitz, P. F. AU - Prendergast, G. C. PY - 1999 DA - 1999// TI - Cell growth inhibition by farnesyltransferase inhibitors is mediated by gain of geranylgeranylated RhoB JO - Mol. Cell. Biol. VL - 19 UR - https://doi.org/10.1128/MCB.19.3.1831 DO - 10.1128/MCB.19.3.1831 ID - Du1999 ER - TY - JOUR AU - Sepp-Lorenzino, L. AU - Ma, Z. AU - Rands, E. PY - 1995 DA - 1995// TI - A peptidomimetic inhibitor of farnesyl:protein transferase blocks the anchorage-dependent and -independent growth of human tumor cell lines JO - Cancer Res. VL - 55 ID - Sepp-Lorenzino1995 ER - TY - JOUR AU - Kohl, N. E. AU - Omer, C. A. AU - Conner, M. W. PY - 1995 DA - 1995// TI - Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice JO - Nat. Med. VL - 1 UR - https://doi.org/10.1038/nm0895-792 DO - 10.1038/nm0895-792 ID - Kohl1995 ER - TY - STD TI - Norgaard P, Law B, Joseph H, et al. Treatment with farnesylprotein transferase inhibitor induces regression of mammary tumors in transforming growth factor (TGF) alpha and TGF alpha/neu transgenic mice by inhibition of mitogenic activity and induction of apoptosis. Clin. Cancer Res.5: 35–42. ID - ref13 ER - TY - JOUR AU - Law, B. K. AU - Norgaard, P. AU - Gnudi, L. PY - 1999 DA - 1999// TI - Inhibition of DNA synthesis by a farnesyltransferase inhibitor involves inhibition of the p70(s6k) pathway JO - J. Biol. Chem. VL - 274 UR - https://doi.org/10.1074/jbc.274.8.4743 DO - 10.1074/jbc.274.8.4743 ID - Law1999 ER - TY - JOUR AU - Mahgoub, N. AU - Taylor, B. R. AU - Gratiot, M. PY - 1999 DA - 1999// TI - In vitro and in vivo effects of a farnesyltransferase inhibitor on Nf1-deficient hematopoietic cells JO - Blood VL - 94 ID - Mahgoub1999 ER - TY - JOUR AU - Blink, B. AU - Juffermans, N. P. AU - Hove, T. PY - 2001 DA - 2001// TI - p38 mitogen-activated protein kinase inhibition increases cytokine release by macrophages in vitro and during infection in vivo JO - J. Immunol. VL - 166 UR - https://doi.org/10.4049/jimmunol.166.1.582 DO - 10.4049/jimmunol.166.1.582 ID - Blink2001 ER - TY - JOUR AU - Sebolt-Leopold, J. S. AU - Dudley, D. T. AU - Herrera, R. PY - 1999 DA - 1999// TI - Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo JO - Nat. Med. VL - 5 UR - https://doi.org/10.1038/10533 DO - 10.1038/10533 ID - Sebolt-Leopold1999 ER - TY - JOUR AU - Branger, J. AU - Blink, B. AU - Weijer, S. PY - 2002 DA - 2002// TI - Antiinflammatory effects of a p38 mitogen-activated protein kinase inhibitor during human endotoxemia JO - J. Immunol. VL - 168 UR - https://doi.org/10.4049/jimmunol.168.8.4070 DO - 10.4049/jimmunol.168.8.4070 ID - Branger2002 ER - TY - JOUR AU - Hommes, D. AU - Blink, B. AU - Plasse, T. PY - 2002 DA - 2002// TI - Inhibition of stress-activated MAP kinases induces clinical improvement in moderate to severe Crohn’s disease JO - Gastroenterology VL - 122 UR - https://doi.org/10.1053/gast.2002.30770 DO - 10.1053/gast.2002.30770 ID - Hommes2002 ER - TY - JOUR AU - Mizukami, Y. AU - Ura, H. AU - Obara, T. PY - 2001 DA - 2001// TI - Requirement of c-jun N-terminal kinase for apoptotic cell death induced by farnesyltransferase inhibitor, farnesylamine, in human pancreatic cancer cells JO - Biochem. Biophys. Res. Commun. VL - 288 UR - https://doi.org/10.1006/bbrc.2001.5744 DO - 10.1006/bbrc.2001.5744 ID - Mizukami2001 ER - TY - JOUR AU - Kolch, W. AU - Heidecker, G. AU - Kochs, G. PY - 1993 DA - 1993// TI - Protein kinase C alpha activates RAF-1 by direct phosphorylation JO - Nature VL - 364 UR - https://doi.org/10.1038/364249a0 DO - 10.1038/364249a0 ID - Kolch1993 ER - TY - JOUR AU - Lebowitz, P. F. AU - Davide, J. P. AU - Prendergast, G. C. PY - 1995 DA - 1995// TI - Evidence that farnesyltransferase inhibitors suppress Ras transformation by interfering with Rho activity JO - Mol. Cell. Biol. VL - 15 UR - https://doi.org/10.1128/MCB.15.12.6613 DO - 10.1128/MCB.15.12.6613 ID - Lebowitz1995 ER -