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Table 1 Time (min) after which amyloid-like fibrils appeared, as revealed by Congo red staining, when IAPP (50 µ M) and three different concentrations of fatty acids were co-incubated

From: Effects of Free Fatty Acid on Polymerization of Islet Amyloid Polypeptide (IAPP) In Vitro and on Amyloid Fibril Formation in Cultivated Isolated Islets of Transgenic Mice Overexpressing Human IAPP

    

Concentration of Fatty Acid* ( µ M)

 

500

50

0.5

0

IAPP alone

360

Myristic acid + IAPP

30

30

30

 

Oleic acid + IAPP

30

30

60

 

Palmitic acid + IAPP

30

30

30

 

Linoleic acid + IAPP

30

30

360

 

Stearic acid + IAPP

30

30

30

 
  1. Results are from one out of three independent experiments, which all gave the same results.