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Fig. 8 | Molecular Medicine

Fig. 8

From: Adenoviral Transfer of mda-7 Leads to BAX Up-regulation and Apoptosis in Mesothelioma Cells, and is Abrogated by Over-expression of BCL-XL

Fig. 8

Caspase-3 activation (cleavage) following Ad-mda7 exposure. (8A) I-45xl and I-45gfp are compared as to functional caspase activity (Y axis). Caspase-3 cleavage is attenuated in I-45xl after Ad-mda7 treatment. (8B) Active caspase-3 activity assay results in the I-45 mesothelioma cell line demonstrating abrogation of caspase activation with both inhibitor (INH) following Ad-mda7 exposure in both I-45gfp and I-45xl, as well as an attenuation of caspase-3 activity in I-45xl compared to I-45gfp.

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Molecular Medicine

ISSN: 1528-3658