Table 1 Survival of wild-type ( cd39 +/+ ) and knockout ( cd39 −/− ) mouse cardiac xenografts
From: Modulation of Nucleotide Triphosphate Diphosphohydrolase-1 (NTPDase-1)/cd39 in Xenograft Rejection
Donor | Treatment of recipient | Graft survival times |
|---|---|---|
Wild type | Presensitized | 10, 20, 20 min |
Knockout | Presensitized | 10, 15, 40 min |
Wild type | Presensitized + CVF | 36, 36, 48, 48, 48 hr |
Knockout | Presensitized + CVF | 14, 16, 24, 24, 36 hr |
Wild type | Nil | 2 days (n = 4) |
Knockout | Nil | 2 days (n = 1) |
Wild type | CVF | 4 days (n = 3) |
Knockout | CVF | 4 days (n = 1) |
Wild type | CVF + CsA | >45 days (n = 6) |
Knockout | CVF + CsA | >45 days (n = 4) |