Table 1 Effect of a functional mutation in CFTR on global gene expression

Close to the y-axis (ΔF changes while wt ∼ parental)

E2n

Interleukin-6 receptor

0.74

0.77

2.42

***

3.0

M20566

D3b

DNA binding protein (DB1)

10.79

7.96

21.58

**

2.6

D28118

E3m

Cytokine receptor (EB13)

0.60

0.46

1.16

**

2.5

L08187

A7l

Cell cycle control protein (C-1)

1.59

1.65

3.77

**

2.2

U41816

D4j

DNA-binding protein (NF-E1)

27.40

28.05

60.83

**

2.1

M76541

A4c

Breast cancer susceptibility (BRCA2)

0.43

0.57

1.22

**

2.0

U43746

E1j

PDGF-alpha receptor

1.98

2.43

0.88

**

2.7

M21574

E5f

Lymphocyte activation antigen CD30

3.96

5.32

2.03

**

2.6

M83554

A7e

Cell cycle control protein Tob

1.43

1.02

0.39

**

2.5

D38305

B7m

Heat shock protein (HSP 70)

0.47

0.37

0.16

**

2.3

M11717

E1k

PDGF-beta receptor

5.95

5.04

2.22

**

2.2

M21616

E7n

Semaphorin (CD100)

1.33

0.96

0.44

**

2.1

U60800

Close to the x-axis (wt changes while ΔF ∼ parental)

E3n

Interleukin 12 receptor component

0.26

0.11

0.34

***

3.1

U03187

D7a

GATA-3 transcription factor

3.92

1.81

4.59

**

2.5

X55122

E2j

NGFR-related B-lymphocyte activation molecule

14.21

32.25

11.00

**

2.9

X60592

F4e

Connective tissue growth factor

0.27

0.45

0.18

**

2.5

M92934

F5d

Neutrophil-activating peptide ENA-78

0.58

1.08

0.43

**

2.5

X78686

C6g

Replication factor C 40-kDa subunit (A1)

0.71

2.64

1.15

**

2.2

M87338

Distant from both x- and y-axes

A5c

AXL tyrosine kinase receptor

1.52

4.16

14.67

***

3.3

M76125

A6j

Cyclin H

1.18

2.41

5.52

**

2.2

U11791

C6c

ATP-dependent DNA helicase II 70-kDa subunit

0.57

0.95

2.07

**

2.1

M32865

F4a

Growth/differentiation factor GDF-1

0.37

0.26

0.55

**

2.0

M62302

D6i

HOX A1 homeodomain protein (HOXA1)

2.50

3.43

1.45

**

2.3

U10421

D6l

DNA binding protein (ard-1)

37.06

54.18

25.42

**

2.0

U14575

B1f

Coagulating factor II receptor

18.55

29.24

13.01

**

2.1

M62424

F7n

Beta-preprotachykinin

0.59

0.76

0.34

**

2.1

X54469