Table 2 Effects of CPX on global gene expression in wild-type and ΔF508-CFTR cells

B5m

PKA regulatory subunit RIβ

5.78

2.44

2.56

203.3

234.8

***

6.0

B51

Protein-tyrosine kinase (JAK1)

0.39

0.19

0.19

10.42

8.20

***

4.9

B5n

Extracellular signal-regulated kinase 2

2.21

1.24

0.77

18.89

27.82

***

4.7

B6m

MAPKAP kinase (3pK)

0.40

0.18

0.11

4.16

2.42

***

4.1

B6n

Receptor tyrosine kinase ligand LERK-3 (EPLG3)

0.30

0.12

0.12

2.40

1.65

***

3.4

D4j

DNA-binding protein (NF-E1)

27.40

28.05

60.83

3.75

4.64

***

3.4

B7k

Heat shock protein hsp86

0.31

0.17

0.19

1.76

2.41

***

3.3

E5h

Intercellular adhesion molecule −1 (ICAM-1)

4.70

3.51

3.92

34.72

42.56

***

3.1

B4d

Active transcription factor CREB

0.61

0.29

0.29

1.31

2.57

**

2.9

D3b

DB1

10.79

7.96

21.58

2.18

2.50

**

2.8

F6b

Interleukin-6 (IL-6) precursor

1.19

0.39

0.43

5.73

3.07

**

2.6

A1a

c-myc oncogene

0.56

0.26

0.30

1.91

2.03

**

2.5

F2n

Macrophage inflammatory protein GOS19-1

0.09

0.07

0.07

0.39

0.43

**

2.5

B5k

cAMP-dependent protein kinase subunit RII-beta

0.24

0.16

0.16

1.32

0.95

**

2.4

C5d

CD40 receptor associated factor 1 (CRAF1)

0.53

1.11

1.98

8.84

11.80

**

2.4

D2b

Basic transcription factor 44 kDa subunit

19.53

16.11

25.90

6.19

4.40

**

2.3

F3h

Nerve growth factor HBNF-1

1.57

2.92

4.64

0.66

0.81

**

2.3

D6h

Nuclear factor NF90

41.78

38.40

18.80

5.58

3.41

**

2.3

D2n

ZFM1 protein alternatively spliced product

0.70

0.83

0.67

2.67

3.59

**

2.2

D2a

CCAAT displacement protein cut homolog alt splice 1

4.42

1.41

2.21

0.83

0.43

**

2.2

D4l

Homeobox protein (HOX-11)

1.65

1.57

2.54

0.34

0.51

**

2.1

C3b

Glutathione S-transferase pi

1.51

0.57

0.53

8.34

2.55

**

2.1

F5l

Interleukin-1 alpha precursor (pre IL-1)

0.60

1.02

1.98

0.43

0.42

**

2.0

A1d

c-kit protooncogene

0.44

0.32

0.37

1.11

1.77

**

2.0

C3i

Fas ligand (FASL)

0.98

1.35

2.44

0.37

0.52

**

2.0

B4k

Mutant lymphocyte-specific protein tyrosine kinase (LCK)

0.34

0.14

0.13

0.77

0.59

**

2.0

C2k

Retinoid X receptor beta (RXR-beta)

7.51

5.51

5.88

1.96

1.27

**

2.0

F2l

Bone morphogenetic protein 2a

0.25

0.18

0.32

1.14

1.41

*

2.0