Table 1 Vectors used and their characteristics

First-generation

E1, E3 (dl309)

AdJM17ΔE1

Contains no transgene, based upon adenoviral vector pJM17 (55) (see methods)

First-generation

E1

AdhAATΔE1

Phosphoglycerate kinase promoter driving expression of human α₁-antitrypsin (hAAT) (29); based upon adenoviral vector pBHGE3 (78)

First-generation

E1, E3

AdhAFPΔE1E3

CAG promoter (79,80) driving expression of human α-fetoprotein (hAFP) (W. O’Neal, unpublished). Based upon adenoviral vector pBHG10 (78)

First-generation

E1

AdyβgalΔE1

Expresses nuclear-targeted β-galactosidase; (29) CMV promoter; based upon adenoviral vector pBHGE3 (78)

Helper-dependent

All

AdSTK109

Contains endogenous hAAT gene, including promoter region (37)