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Fig. 2 | Molecular Medicine

Fig. 2

From: Altered Expression of the Cell Cycle Regulatory Molecules pRb, p53 and MDM2 Exert a Synergetic Effect on Tumor Growth and Chromosomal Instability in Non-small Cell Lung Carcinomas (NSCLCs)

Fig. 2

Representative immunohistochemical results (see Methods). (A) Squamous cell lung carcinoma (case 6) with heterogenous aberrant pRb expression (see Methods). Streptavidin-biotin peroxidase technique with “Rb1” anti-pRb antibody and hematoxylin counterstain (X400). [Thick and thin] arrows indicate an “Rb1” positive and negative portion of the tumor area, respectively; whereas, an “Rb1” positive stromal cell is pointed by a small arrow. (B) Squamous cell lung carcinoma (case 3) with MDM2 protein overexpression. Streptavidin-biotin peroxidase technique with “SMP14” anti-MDM2 antibody (DAB as chromogen) and hematoxylin counterstain (X200). (C) Squamous cell lung carcinoma (case 62) with high proliferative activity (proliferation index, PI = 41%). Streptavidin-biotin peroxidase technique (DAB as chromogen) with “MIB-1” anti-Ki67 antibody and hematoxylin counterstain (X400).

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Molecular Medicine

ISSN: 1528-3658