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Table 2 Association among pRb, p53, MDM2, pRb/p53/MDM2 patterns, number of alterations and clinicopathological features, proliferation index, apoptotic rate and ploidy status

From: Altered Expression of the Cell Cycle Regulatory Molecules pRb, p53 and MDM2 Exert a Synergetic Effect on Tumor Growth and Chromosomal Instability in Non-small Cell Lung Carcinomas (NSCLCs)

Expression

Smoking History

 

Histology

Lymph Node Invasion

 

Stage

 

Proliferation Index

 

Apoptotic Index

 

Ploidy Status

 
  

No

Yes

p

SQ

AD

UL

 

+

p

I

II

III

p

Mean (n)

StDev

p

Mean (n)

StDev

p

A

D

p

pRb IHC

Ab

5

28

1

14

17

2

0.876

15

18

1

13

10

10

0.788

37.88(32)

11.34

0.002

1.174(31)

1.029

0.006

23

9

0.034

 

No

8

44

 

25

24

3

 

24

27

22

17

12

  

30.65(48)

9.95

 

2.223(41)

2.21

 

23

25

 

p53 IHC

P

4

45

0.064

26

20

3

0.268

21

27

0.66

16

16

16

0.129

36.71(46)

11.32

0.001

1.353(43)

1.28

0.011

31

15

0.037

 

N

9

27

 

13

21

2

 

18

18

 

19

11

6

 

29.26(34)

9.2

 

2.390(29)

2.39

 

15

19

 

MDM2 IHC

P

8

49

0.751

26

26

5

0.259

23

34

0.159

21

20

16

0.426

36.02(53)

11.26

0.001

1.450(48)

1.409

0.004

38

15

<0.001

 

N

5

23

 

13

15

 

16

11

 

14

7

6

 

28.68(27)

8.96

 

2.420(24)

2.45

 

8

19

 

pRb/p53/MDM2

No/N/N

2

11

0.295

6

7

0.759

9

4

0.615

9

3

1

0.153

28.59(13)

9.13

0.001

3.460(12)

3.063

0.022

4

10

0.034

 

Ab/N/N

1

2

 

3

 

1

2

 

1

2

 

22.57(3)

3.67

 

1350(3)

1.236

 

1

2

 
 

No/P/N

2

8

 

4

6

 

5

4

 

4

2

3

 

28.64(9)

7.36

 

1.327(7)

0.823

 

2

6

 
 

No/N/P

4

11

 

7

6

2

 

5

10

 

5

5

5

 

31.25(13)

9.43

 

1.850(10)

1.584

 

8

5

 
 

Ab/P/N

2

 

1

1

 

1

1

 

2

 

38.60(2)

17.82

 

1.633(2)

1.321

 

1

1

 
 

Ab/N/P

2

3

 

4

1

 

3

2

 

4

1

 

29.84(5)

11.22

 

1.329(4)

1.455

 

2

2

 
 

No/P/P

14

 

6

7

1

 

5

9

 

4

7

3

 

33.49(13)

12.75

 

1.824(12)

1.865

 

9

4

 
 

Ab/P/P

2

21

 

9

12

2

 

10

13

 

8

7

8

 

41.74(22)

9.22

 

1.080(22)

0.972

 

18

4

 

Alterations

0

              

28.59(13)

9.13

<0.001

3.457(12)

3.063

0.001

3

9

0.011

 

1

              

29.27(25)

8.46

 

1.629(20)

1.241

 

12

14

 
 

2

              

33.11(18)

12.33

 

1.693(18)

1.665

 

12

7

 
 

3

              

41.74(22)

9.22

 

1.080(20)

0.972

 

19

4

 
  1. A, Aneuploid; Ab, Aberrant; AD, Adenocarcinoma; D, Diploid; N, Negative; No, Normal; P, Positive; SQ, Squamous cell carcinoma; UL, Undifferentiated Large cell carcinoma.