Expression | Smoking History | Histology | Lymph Node Invasion | Stage | Proliferation Index | Apoptotic Index | Ploidy Status | |||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No | Yes | p | SQ | AD | UL | − | + | p | I | II | III | p | Mean (n) | StDev | p | Mean (n) | StDev | p | A | D | p | |||
pRb IHC | Ab | 5 | 28 | 1 | 14 | 17 | 2 | 0.876 | 15 | 18 | 1 | 13 | 10 | 10 | 0.788 | 37.88(32) | 11.34 | 0.002 | 1.174(31) | 1.029 | 0.006 | 23 | 9 | 0.034 |
No | 8 | 44 | 25 | 24 | 3 | 24 | 27 | 22 | 17 | 12 | 30.65(48) | 9.95 | 2.223(41) | 2.21 | 23 | 25 | ||||||||
p53 IHC | P | 4 | 45 | 0.064 | 26 | 20 | 3 | 0.268 | 21 | 27 | 0.66 | 16 | 16 | 16 | 0.129 | 36.71(46) | 11.32 | 0.001 | 1.353(43) | 1.28 | 0.011 | 31 | 15 | 0.037 |
N | 9 | 27 | 13 | 21 | 2 | 18 | 18 | 19 | 11 | 6 | 29.26(34) | 9.2 | 2.390(29) | 2.39 | 15 | 19 | ||||||||
MDM2 IHC | P | 8 | 49 | 0.751 | 26 | 26 | 5 | 0.259 | 23 | 34 | 0.159 | 21 | 20 | 16 | 0.426 | 36.02(53) | 11.26 | 0.001 | 1.450(48) | 1.409 | 0.004 | 38 | 15 | <0.001 |
N | 5 | 23 | 13 | 15 | − | 16 | 11 | 14 | 7 | 6 | 28.68(27) | 8.96 | 2.420(24) | 2.45 | 8 | 19 | ||||||||
pRb/p53/MDM2 | No/N/N | 2 | 11 | 0.295 | 6 | 7 | − | 0.759 | 9 | 4 | 0.615 | 9 | 3 | 1 | 0.153 | 28.59(13) | 9.13 | 0.001 | 3.460(12) | 3.063 | 0.022 | 4 | 10 | 0.034 |
Ab/N/N | 1 | 2 | 3 | − | − | 1 | 2 | 1 | 2 | − | 22.57(3) | 3.67 | 1350(3) | 1.236 | 1 | 2 | ||||||||
No/P/N | 2 | 8 | 4 | 6 | − | 5 | 4 | 4 | 2 | 3 | 28.64(9) | 7.36 | 1.327(7) | 0.823 | 2 | 6 | ||||||||
No/N/P | 4 | 11 | 7 | 6 | 2 | 5 | 10 | 5 | 5 | 5 | 31.25(13) | 9.43 | 1.850(10) | 1.584 | 8 | 5 | ||||||||
Ab/P/N | − | 2 | 1 | 1 | − | 1 | 1 | − | − | 2 | 38.60(2) | 17.82 | 1.633(2) | 1.321 | 1 | 1 | ||||||||
Ab/N/P | 2 | 3 | 4 | 1 | − | 3 | 2 | 4 | 1 | − | 29.84(5) | 11.22 | 1.329(4) | 1.455 | 2 | 2 | ||||||||
No/P/P | − | 14 | 6 | 7 | 1 | 5 | 9 | 4 | 7 | 3 | 33.49(13) | 12.75 | 1.824(12) | 1.865 | 9 | 4 | ||||||||
Ab/P/P | 2 | 21 | 9 | 12 | 2 | 10 | 13 | 8 | 7 | 8 | 41.74(22) | 9.22 | 1.080(22) | 0.972 | 18 | 4 | ||||||||
Alterations | 0 | 28.59(13) | 9.13 | <0.001 | 3.457(12) | 3.063 | 0.001 | 3 | 9 | 0.011 | ||||||||||||||
1 | 29.27(25) | 8.46 | 1.629(20) | 1.241 | 12 | 14 | ||||||||||||||||||
2 | 33.11(18) | 12.33 | 1.693(18) | 1.665 | 12 | 7 | ||||||||||||||||||
3 | 41.74(22) | 9.22 | 1.080(20) | 0.972 | 19 | 4 |