Altered Expression of the Cell Cycle Regulatory Molecules pRb, p53 and MDM2 Exert a Synergetic Effect on Tumor Growth and Chromosomal Instability in Non-small Cell Lung Carcinomas (NSCLCs)

Table 3 Association between PI, AI, ploidy status and clinicopathological features

Parameters		Smoking History				Histology			Lymph Node Invasion
		No	Yes	Ρ	SQ	AD	UL	Ρ	−	+	Ρ	I	II	III	Ρ
PI	mean (n)	27.66 (12)	34.61 (68)	0.041	38.42 (39)	28.19 (37)	35.95 (5)	<0.001	32.92 (36)	34.28 (43)	0.829	31.20 (32)	34.59 (25)	36.16 (22)	0.292
	StDev	10.2	10.94		10.13	9.98	7.14		9.99	12.02		10.09	12.85	10.05
AI	mean (n)	1.720 (10)	1.792 (62)	0.672	1,379 (33)	2.091 (36)	2.404 (3)	0.494	1.634 (33)	1.907 (39)	0.505	1.642 (19)	1.796 (24)	1.861 (29)	0.678
	StDev	1.215	1.950		1,036	2.314	1.670		1.917	1.818		1.620	1.889	2.023
Ploidy	a	6	40	0.753	24	18	4	0.069	14	32	0.003	13	18	15	0.031
	D	6	28		11	22	1		22	11		19	7	7

A: Aneuploid, AD: Adenocarcinoma, AI: Apoptotic Index, D: Diploid, PI: Proliferation Index, SQ: Squamous cell carcinoma, UL: Undifferentiated Large cell carcinoma.

ISSN: 1528-3658