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Table 4 Association between PI, AI, PI/AI, ploidy and number of alterations

From: Altered Expression of the Cell Cycle Regulatory Molecules pRb, p53 and MDM2 Exert a Synergetic Effect on Tumor Growth and Chromosomal Instability in Non-small Cell Lung Carcinomas (NSCLCs)

  

Analysis of Variance

Logistic Regression Analysis

  

PI

 

logAI

 

Ploidy

  

Mean Difference(95%CI)

p

Mean Difference(95%CI)

p

Odds Ratio(95%CI)

p

Intercept

 

28.61(23.17, 34.09)

<0.001

0.973(0.501 − 1.444)

<0.001

0.121

3 alterations

 

13.17(6.30, 20.04)

<0.001

−1.145(−1.731, −0.558)

<0.001

−11.87(2.44, 57.85)

0.002

2 alterations

 

4.50(−2.50, 11.49)

0.204

− 0.836(−1.445, 0.227)

0.008

μ4.29(0.97, 18.97)

0.055

1 alteration

 

0.67(−6.40, 7.39)

0.842

− 0.831(−1.423, 0.235)

0.007

μ2.11(0.52, 8.67)

0.298

0 alteration

 

 

 

 
  

Multiple Comparisons’ Analysis

  

PI

logAI

PI/AI

 
  

Mean Difference(95%CI)

p

Mean Difference(95%CI)

p

Mean Difference(95%CI)

p

Intercept

       

3 alterations

LSD

13.17(6.30, 20.04)

<0.001

−1.144(−1.731, −0.558)

<0.001

−48.05(15.83, 80.27)

0.004

 

Scheffe

13.17(3.31, 23.03)

0.004

−1.144(−1.987, −0.302)

0.003

−48.05(1.75, 94.35)

0.039

2 alterations

LSD

4.50(−2.50, 11.49)

0.204

−0.836(−1.445, 0.227)

0.008

−26.80(−6.96, 60.56)

0.118

 

Scheffe

4.50(−5.55, 14.54)

0.652

−0.836(−1.710, 0.039)

0.067

−26.80(−21.71, 75.32)

0.147

1 alteration

LSD

0.67(−6.40, 7.39)

0.842

−0.831(−1.428, 0.235)

0.007

−24.05(−8.70, 56.80)

0.147

 

Scheffe

0.67(−8.97, 10.31)

0.998

−0.831(−1.689, 0.026)

0.061

−24.05(−23.02, 71.11)

0.546

0 alteration

 

 

 

*

 
  

PI

logAI

 

PI/AI

 
  

Mean Difference(95%CI)

p

Mean Difference(95%CI)

p

Mean Difference(95%CI)

p

Intercept

       

0 alteration

LSD

−13.17(−20.04, −6.30)

<0.001

1.144(0.558, 1.731)

<0.001

−48.05(−80.27, −15.83)

0.004

 

Scheffe

−13.17(−23.03, −3.31)

0.004

1.144(0.302, 1.987)

0.003

−48.05(−94.35, −1.75)

0.039

1 alterations

LSD

−12.49(−18.23, −6.75)

<0.001

0.313(−0.192, 0.818)

0.220

−24.00(−50.96, 2.95)

0.080

 

Scheffe

−12.49(−20.73, −4.25)

0.001

0.313(−0.412, 1.039)

0.677

−24.00(−62.74, 14.73)

0.375

2 alterations

LSD

−8.67(−14.74, −2.61)

0.006

0.309(−0.211, 0.828)

0.240

−21.25(−49.43, 6.92)

0.137

 

Scheffe

−8.67(−17.38, 0.04)

0.051

0.309(−0.438, 1.055)

0.705

−21.25(−61.74, 19.24)

0.523

3 alterations

 

 

 

 
  1. PI: Proliferation Index, AI: Apoptotic Index
  2. *Mean Value: 15.18