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Fig. 1 | Molecular Medicine

Fig. 1

From: Efficient Mitochondrial Import of Newly Synthesized Ornithine Transcarbamylase (OTC) and Correction of Secondary Metabolic Alterations in spfash Mice following Gene Therapy of OTC Deficiency

Fig. 1

OTC labeling in infected and uninfected hepatocytes. The ultrathin frozen liver section from a spfash mouse infected with Ad.mOTC was labeled by the rabbit anti-OTC antibody followed with gold-conjugated goat anti-rabbit antisera. The hepatocyte infected with the OTC virus is characterized by enlarged mitochondria and a much higher mitochondrial OTC labeling density (upper right corner) than in the uninfected hepatocyte (lower left corner). TJ, tight junction complex; BC, bile canaliculus; ER, endoplasmic reticulum. Arrows indicate the lateral membrane of the hepatocytes. Bar, 0.1 µm.

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Molecular Medicine

ISSN: 1528-3658