TNF, IL-2 and IFN-γ and their ratios. IGF-I/BP-3 significantly decreased TNF at D 5 II when compared to burned controls (p < 0.05) that demonstrated no change in TNF. Furthermore, IGF-I/BP-3 significantly decreased ratios of TNF/IL-2 and TNF/IFN-γ compared to burn controls that demonstrated no change over the two study periods. With the administration of IGF-I/BP-3 the ratios of TNF/IL-2 and TNF/IFN-γ approached ratios of normal controls. *Significant difference between IGF-I/BP-3 and control at D 5 II (p < 0.05). Data are presented as means ± SEM. Normal values: TNF/IL-2, 0.003–0.005; TNF/IFN-γ, 0.005–0.007.