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Table 2 Serum IGF-I and IGFBP-3, kidney and liver markers five days after the initiation of treatment or control

From: IGF-I/IGFBP-3 Equilibrates Ratios of Pro- to Anti-inflammatory Cytokines, Which Are Predictors for Organ Function in Severely Burned Pediatric Patients

 

Control n = 7

IGF-I/BP-3 n = 17

 

D 5 I

D 5 II

Δ (%)

D 5 I

D 5 II

Δ(%)

IGF-I (µg/ml)

93 ± 9

103 ± 13

10 ± 7

102 ± 15

433 ± 33*‡

382 ± 44*

IGFBP-3 (µg/ml)

1.4 ± 0.2

1.6 ± 0.2

3 ± 8

1.5 ± 0.2

3.0 ± 0.2*‡

88 ± 12*

Creatinine (mg/dl)

3.3 ± 0.5

3.7 ± 0.8

5 ± 3

3.7 ± 0.4

2.3 ± 0.2*‡

−20 ± 9*

Pre-albumin (mg/dl)

9 ± 1

11 ± 1

2 ± 7

11 ± 1

19 ± 1*‡

55 ± 9*

CHE (U/l)

840 ± 10

870 ± 15

3 ± 8

800 ± 15

2200 ± 30*‡

292 ± 40*

  1. Data presented as means ± SEM. Δ is defined as percent change from OP II to D 5 II.
  2. * Significant difference IGF-I/BP-3 vs. control (p < 0.05). ‡ Significant difference D 5 II vs. D 5 I (p < 0.05).
  3. Values for unburned normal children:
  4. IGF-I: 365 ± 15 µg/ml;
  5. IGFBP-3: 2.8 ± 0.9 µg/ml;
  6. Creatinine: 0.5–1.5 mg/dl
  7. Pre-albumin: 25–45 mg/dl
  8. CHE: 2400–8500 U/l.